The CAS REGISTRY, maintained by CAS (a division of the American Chemical Society) in Columbus, Ohio, contains more than 290 million unique substances disclosed in the literature and patents since the early 1900s. It reached 50 million in 2009 and 100 million in 2015, and grows by thousands of substances every day.
The question, scope, and sources behind this Registry record.
The CAS REGISTRY, maintained by CAS (a division of the American Chemical Society) in Columbus, Ohio, contains more than 290 million unique substances disclosed in the literature and patents since the early 1900s. It reached 50 million in 2009 and 100 million in 2015, and grows by thousands of substances every day.
The number of unique organic and inorganic chemical substances recorded in the CAS REGISTRY, the largest database of disclosed chemical substances, as of the stated date.
Change a parameter to stress-test whether a proposed result is still inside the published specification. This is an audit aid, not a proof checker.
This record has no editable parameters. Read the formal question and assumptions before challenging it.
Current frontiers derived from accepted Claims.
An observed or demonstrated result; no opposing bound is implied.
The frontier is not sacred
Most progress starts with a disagreement that survives contact with evidence. If you can push the known lower bound up or pull the upper bound down, show us the work.
≥ when you have shown that at least this value is achievable.≤ when you have shown that anything above this value is impossible.No vibes. State the value, define the scope, and link the paper, proof, code, or reproduction that lets another person check it. Editors review every challenge before the public record changes.
Challenge this recordAssertions tied to evidence, attribution, and review.
The frontier as it changed over time.
Only accepted Claims matching the current specification contribute to the displayed bounds. Strict inequalities remain open; contradictory Claims require editorial review.
1 accepted Claim, with 1 linked evidence records.
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Limits Registry. LR-CAS-REGISTRY-SUBSTANCE-COUNT. Largest registry of known chemical substances. 2026.