Limits RegistryPUBLIC RECORD
Limits RegistryThe upper kinetic regime for enzyme catalytic efficiency is commonly placed near 10⁸–10⁹ M⁻¹ s⁻¹.
The question, scope, and sources behind this Registry record.
The upper kinetic regime for enzyme catalytic efficiency is commonly placed near 10⁸–10⁹ M⁻¹ s⁻¹.
Track enzyme systems whose k_cat/K_M approaches the diffusion-controlled encounter limit in aqueous solution.
Catalytic efficiency approaches a diffusion-controlled ceiling when substrate encounter and productive orientation become rate limiting. The frontier depends on solvent viscosity, electrostatic steering, substrate definition, and whether the reported rate is steady-state or pre-steady-state.
World Health Organization data and guidelines — Diffusion-limited enzyme catalytic efficiencyChange a parameter to stress-test whether a proposed result is still inside the published specification. This is an audit aid, not a proof checker.
Current frontiers derived from accepted Claims.
The frontier is not sacred
Most progress starts with a disagreement that survives contact with evidence. If you can push the known lower bound up or pull the upper bound down, show us the work.
≥ when you have shown that at least this value is achievable.≤ when you have shown that anything above this value is impossible.No vibes. State the value, define the scope, and link the paper, proof, code, or reproduction that lets another person check it. Editors review every challenge before the public record changes.
Challenge this recordAssertions tied to evidence, attribution, and review.
The frontier as it changed over time.
Only accepted Claims matching the current specification contribute to the displayed bounds. Strict inequalities remain open; contradictory Claims require editorial review.
Permanent ID limitsregistry.com/limits/LR-004209
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Limits Registry. LR-004209. Diffusion-limited enzyme catalytic efficiency. 2026.