Limits RegistryPUBLIC RECORD
Limits RegistrySmall single-domain proteins can fold on microsecond timescales, with engineered ultrafast folders reported near 4 μs.
The question, scope, and sources behind this Registry record.
Small single-domain proteins can fold on microsecond timescales, with engineered ultrafast folders reported near 4 μs.
Track the shortest experimentally resolved folding relaxation time for a small, single-domain protein under defined solution conditions.
Protein folding speed is defined relative to a structural reaction coordinate and a temperature or perturbation protocol. The record is useful as a kinetic frontier while remaining dependent on protein sequence, solvent, and experimental definition.
World Health Organization data and guidelines — Fast protein-folding timescaleChange a parameter to stress-test whether a proposed result is still inside the published specification. This is an audit aid, not a proof checker.
Current frontiers derived from accepted Claims.
The frontier is not sacred
Most progress starts with a disagreement that survives contact with evidence. If you can push the known lower bound up or pull the upper bound down, show us the work.
≥ when you have shown that at least this value is achievable.≤ when you have shown that anything above this value is impossible.No vibes. State the value, define the scope, and link the paper, proof, code, or reproduction that lets another person check it. Editors review every challenge before the public record changes.
Challenge this recordAssertions tied to evidence, attribution, and review.
The frontier as it changed over time.
Only accepted Claims matching the current specification contribute to the displayed bounds. Strict inequalities remain open; contradictory Claims require editorial review.
Permanent ID limitsregistry.com/limits/LR-004207
No active verified bounties are linked to this Limit.
View verified bounty tracker ↗No accepted machine-checked reproductions are recorded for this Limit.
Limits Registry. LR-004207. Fast protein-folding timescale. 2026.